hrp0082p1-d1-144 | Growth | ESPE2014

Genetics of Growth Failure in Small for Gestational Age Children

Keppler Romy , van der Werft-Grohmann Natascha , Schwab Karl Otfried , Lausch Ekkehart

Background: Small for gestational age (SGA), defined as ≤−2.0 SDS birth length or weight, is a condition seen in up to 3% of all newborn. Most SGA children catch up height in postnatal life. In a significant number (~10%), however, height remains below the third centile. Recombinant GH therapy is indicated when growth failure continues to 4 years of age. The pathophysiological basis of SGA is complex: monogenic disorders and/or fetal programming by environmental fa...